Dietary Calorie Restriction as an Epigenetic Rejuvenator in Aging- Induced Decline of Cognitive Function

Calorie Restriction, Longevity and Cognitive Function

calorie restriction, longevity and cognitive function

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Aging, adiposity, and calorie restriction.

CONTEXT Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span. OBJECTIVE To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient...

Calorie restriction as an intervention in ageing

Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory process and affects life- and healthspan. Calorie restriction (CR) is a non-genetic intervention that prevents age-associated diseases and extends longevity in most of the animal models studied so far. CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to th...

Calorie restriction and aging in nonhuman primates.

In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake extends the lifespan of rats, a great deal has been learned about the effects of calorie restriction (CR; reduced intake of a nutritious diet) on aging in various short-lived animal models. Studies have demonstrated many beneficial effects of CR on health, the rate of aging, and longevity. Two prospe...